AFC Utsukushhii Gold

The Convergence of Patented Science & Nature for Cellular Health

Engineered for Synergy:

The Three Foundational Pillars

1. The 8-Patent Foundation

A blueprint for targeted therapeutic action, forming the core of the product's efficacy.

2. The 3-Probiotic Core

The living engine for gut microbiota balance and systemic immune modulation.

3. The Synergistic Amplifiers

A curated matrix of marine and botanical bioactives that enhance and expand the formula's effects.

PILLAR 1 :

The Formula is Built on Eight Distinct Patents, Representing a Multi-Targeted Strategy for Health and Resilience

These patents represent decades of research into microbial immunology, natural product chemistry, and cellular regeneration, forming the foundation of Utsukushhii Gold's efficacy.

Patent 1: JP3040711B2

Training the Body's Immune System to fight Cancer Cells

without harming Healthy Tissue.

The Problem

Conventional chemotherapy damages both cancerous and healthy, fast-dividing cells (e.g., bone marrow, intestinal lining), causing severe side effects like immunosuppression.

The Patented Solution

Utilizes heat-killed Enterococcus bacteria to stimulate and train the host's immune system to specifically recognize and attack cancer cells,

preserving healthy tissue and empowering the body's natural defenses.

Patents 2 & 3: JP3272023B2 & JP2969017B2

Activating Immunity, preventing Leukopenia, and

providing Broad-Spectrum Infection Protection.

Mechanism 1 (Leukopenia Prevention) Addresses leukopenia (a dangerous drop in white blood cells) by using heat-killed Enterococcus to stimulate bone marrow production of immune cells.

Mechanism 2 (Infection Defense)

Employs competitive exclusion in the gut, where beneficial bacteria occupy space to block pathogens. This stimulates secretory IgA antibodies, the first line of mucosal defense.

Patent 4: JP2712000B2

A Novel Immunomodulatory Approach

to empower the Body to clear Hepatitis C Virus

The Challenge

Traditional antiviral therapies for Hepatitis C are often insufficient or have intolerable side effects.

The Patented Solution

Oral administration of killed lactic acid bacteria boosts the body's cell-mediated immunity. This activates Natural Killer (NK) cells and cytotoxic T lymphocytes to specifically target and eliminate virus-infected liver cells, enabling the body to naturally suppress the virus.

Patent 5 & 6: JP5635690B2 & JP3040699B2

Suppressing Tumor Growth with Biological Nanocarriers and

Shielding Kidneys from Chemotherapy Damage

Innovation 1 (Tumor Suppression)

Utilizes bacterial-derived microvesicles (20-200 nm) as biological nanocarriers. These can be engineered to deliver anticancer drugs directly to tumor sites, enhancing efficacy and reducing systemic toxicity.

Innovation 2 (Nephrotoxicity Reduction)

Uses Enterococcus faecalis NF-1011 to dramatically reduce the kidney damage (nephrotoxicity) caused by the potent chemotherapy agent cisplatin, allowing for more effective treatment protocols.

Patents 7 & 8: US7048953B2 & JP5697788B1

Preventing Respiratory Infections and Combating Oxidative Stress with Unique Bacterial Strains

Protection 1 (Respiratory)

A US patent for preventing respiratory infections (including SARS, influenza) via inhalation of vapors from antimicrobial essential oils like eucalyptus and tea tree oil.

Protection 2 (Cellular)

Features a novel lactic acid bacterium isolated from salmon intestine. This strain shows exceptional capacity to adsorb cholesterol and bile acids and provides superior antioxidant protection due to its

unique marine adaptation.

Pillar 2: The Living Engine of Gut and Immune Health

Lactococcus lactis:

The Immune Modulator.

A powerful immune trainer that reduces inflammation, exhibits anti-tumor properties, and increases anti-inflammatory IL-10 by up to 50%.

Lactic Acid Bacteria (LAB):

The Immune Conductor.

Master regulators that boost Natural Killer (NK) cell activity by up to 400% and increase lymphocyte proliferation by 60%, orchestrating a coordinated immune response.

Bifidobacterium longum:

The Gut Specialist.

Excels at relieving IBS symptoms, strengthening the gut barrier, and positively influencing the gut-brain axis for improved mental well-being.

A Synergistic Trio for Exponential Benefits

The Synergy Explained:

The strains work in concert with spatial complementarity. L. lactis and LAB create the ideal acidic environment in the upper GI tract, allowing B. longum to thrive in the colon. This ensures comprehensive gut coverage and a balanced, powerful immune response.

Reduction in tumor formation rates

(Lactococcus lactis in mouse models)

Increase in Natural Killer (NK) cell activity (Lactic Acid Bacteria)

Increase in anti-inflammatory IL-10

(Lactococcus lactis in colitis models)

Lactococcus lactis:

A Potent Immune Trainer and Anti-Tumor Agent

that Restores Gut Balance.

Key Functions

Immune Modulation: Increases anti-inflammatory IL-10 by up to 50% in colitis models and enhances mucosal defense (sIgA).

Anti-Tumor Properties: A 2024 study

showed it reduced colorectal cancer (CRC) occurrence through multiple mechanisms.

The Data

In mouse models, L. lactis administration resulted in an 86% reduction in tumor formation rates and a 65% decrease in tumor volumes.

Lactic Acid Bacteria (LAB):

Master Regulators that can increase

Natural Killer (NK) Cell Activity by up to 400%.

Key Functions

Immune Stimulation: Broadly stimulates both innate (NK cells, macrophages) and adaptive (lymphocytes) immunity.

Performance Data

Increases NK cell activity by 400% and lymphocyte proliferation by 60% within two weeks of supplementation.

Additional Benefits

Strengthens the intestinal barrier to prevent "leaky gut", enhances vaccine efficacy, and reduces chronic inflammation by inhibiting NF-κB.

Bifidobacterium Longum:

The Gut Health Specialist that

fights Inflammation, Relieves IBS, and

positively influences the Gut-Brain Axis

Key Functions

Gut Health: Produces butyrate to nourish colon cells, improves remission in Ulcerative Colitis, and provides significant relief from IBS

Gut-Brain Axis: The 1714 strain has been shown to improve sleep quality, enhance vitality, and reduce mental fatigue in stressed adults.

Immune Action: Produces a serpin (serine protease inhibitor) that can block elastase, an enzyme involved in inflammatory damage.

Pilar 3:

Marine & Botanical Powerhouses

Salmon DNA (PDRN):

The cellular regeneration engine. Activates adenosine A2a receptors to stimulate fibroblasts, increasing collagen (+25%) and hyaluronic acid (+30%) for tissue repair and skin rejuvenation.

Takara Kombu Fucoidan:

The marine immune modulator. Induces apoptosis (programmed cell death) in cancer cells, inhibits tumor angiogenesis (blood vessel formation), and activates NK cells.

Black Garlic:

The antioxidant titan. An aging process increases antioxidant power up to 10x that of fresh garlic, protecting cells from oxidative stress and exhibiting direct cytotoxicity to cancer cells.

Salmon DNA (PDRN):

A Regenerative Powerhouse that stimulates Collagen,

accelerates Tissue Repair, and primes the Immune System

Mechanism of Action

Polydeoxyribonucleotides (PDRN) activate adenosine A2a receptors on cells, triggering cascades that stimulate tissue repair and reduce inflammation.

Quantifiable Results

Promotes fibroblast activity, leading to an increase in collagen synthesis by +25% and hyaluronic acid production by +30%.

Additional Benefit

Promotes angiogenesis (new blood vessel formation) for enhanced healing and primes the immune system via the CGAS-STING pathway.

Takara Kombu Fucoidan:

The Marine Bioactive that induces Cancer Cell Apoptosis

and blocks Tumor Blood Supply

Three Primary Anti-Cancer Actions

1. Induces Apoptosis

Triggers programmed cell death selectively in cancer cells.

2. Inhibits Angiogenesis

Blocks VEGF signaling to prevent the formation of new blood vessels that tumors need to grow.

3. Activates Immunity

Enhances the cytotoxicity of NK cells and macrophages, enabling them to destroy cancer cells

more effectively.

Black Garlic:

Aged to achieve over 10x the Antioxidant Power of Fresh Garlic, protecting cells from Oxidative Damage.

The Science of Aging

A controlled fermentation process converts allicin into stable, potent antioxidants like S-allyl-cysteine (SAC).

Superior Antioxidant Power

Exhibits a 4.5-fold higher TEAC (Trolox equivalent antioxidant capacity) value than fresh garlic (59.2 vs 13.3 μmol/g).

Anti-inflammatory Action

Suppresses inflammation by inhibiting key pathways like NF-kB and enzymes like COX-2.

A Matrix of Synergistic Ingredients for Comprehensive Support.

Benefit 1

The Result: Gut Optimization & Liver Fortification

Gut Health & Colon Cancer Prevention

The probiotic trio restores microbiota balance and strengthens the gut barrier to prevent "leaky gut."

Fucoidan acts as a prebiotic, nourishing beneficial bacteria.

L. lactis is shown to reduce tumor formation rates by over 80% in models by reducing carcinogenic secondary bile acids and inflammation.

Liver Support & Detoxification

Patent 3 (Therapeutic Agent for Hepatitis) directly

Supports the liver through immune enhancement. L-Glutathione, the liver's primary antioxidant, enhances Phase I and II detoxification pathways.


Black Garlic and Fucoidan protect hepatocytes from damage and reduce inflammation.

Optimizing the Gut Microbiome to prevent "Leaky Gut,"

reduce Inflammation, and mitigate Colorectal Cancer Risk

Summary of Actions

Probiotics restore balance, strengthen the intestinal barrier, and produce anti-inflammatory butyrate ✗. Fucoidan acts

as a prebiotic. This synergy dramatically reduces factors linked to colorectal cancer.

Key Outcome

Probiotic intervention and supporting nutrients ✓ down-regulate pyrimidine metabolism needed for cancer cell

growth and reduce carcinogenic secondary bile acids, leading to significant risk reduction.

Enhancing the Live Liver's 500+ Functions, from

Detoxification to Metabolism, for Peak Performance

Multi-Pronged Support

  • Antiviral: Patent 3 technology helps the immune system address viral hepatitis.
  • Detoxification: L-Glutathione enhances Phase I & II detox pathways.
  • Protection: Black Garlic and Fucoidan protect hepatocytes from damage and reduce fibrosis.
  • Metabolism: Patent 8's salmon-derived probiotic reduces hepatic fat accumulation (NAFLD).

Creating a vigilant, balanced, and resilient Immune System that fights infection while preventing Over-inflammation

Synergistic Action

Probiotics train innate and adaptive immunity. Fucoidan stimulates cytotoxicity. Vitamin D modulates T-cells. Glutathione fuels immune cells. Together, they create a response that is both powerful and controlled.

The Outcome

An optimized immune system that responds vigorously to pathogens and cancer cells, but avoids the excessive, chronic inflammation and autoimmune reactions that underlie modern disease.

Benefit 2

The Result: Immune Modulation & Multi-Targeted Cancer Defense

Immune System Enhancement

A synergistic effect where Probiotics, Fucoidan, Vitamin D, and Black Garlic work together to activate the full spectrum of immune cells: NK cells, macrophages, T-cells, and B-cells.

Multi-Pronged Anti-Cancer Action

Immune Training: Patents 1 & 4 empower the body's natural defenses.

Apoptosis Induction: Fucoidan selectively triggers cancer cell death.

Anti-Angiogenesis: Fucoidan starves tumors by blocking their blood supply.

O Direct Cytotoxicity: Black Garlic is toxic to lung, breast, stomach, and liver cancer cells.

Chemotherapy Toxicity Reduction: Patent 5

protects the kidneys.


A Multi-Targeted Approach to Cancer Prevention and Adjuvant Therapy

Summary of Mechanisms

  • Immune Training (Patent 1)
  • Apoptosis Induction (Fucoidan)
  • Angiogenesis Inhibition (Fucoidan)
  • Direct Cytotoxicity (Black Garlic)
  • Inflammation Reduction (Probiotics, Resveratrol)
  • Chemotherapy Support (Patent 5)

Benefit 3

The Result: Cellular Protection & Skin Rejuvenation

Oxidative Stress Reduction

A powerful antioxidant shield created by Black Garlic, Resveratrol, Kiwi Seed Extract, and L-Glutathione that neutralizes free radicals and activates the body's own defense systems via Nrf2.

Skin Regeneration & Structural Support

• Salmon DNA stimulates fibroblasts to produce more collagen and hyaluronic acid, improving elasticity and hydration.

• Fish Collagen provides bioavailable peptides as the direct building blocks for improving skin moisture and reducing wrinkles.

Rejuvenating Skin from within by stimulating Collagen,

enhancing Hydration, and protecting against Oxidative Aging

Internal Mechanisms

O Rebuilding: Salmon DNA (PDRN) and Fish Collagen stimulate fibroblasts and provide building blocks to increase collagen and elastin.

Hydrating: PDRN increases hyaluronic acid production for improved moisture.

Protecting: Antioxidants (Black Garlic, Resveratrol) protect against UV and pollutant damage, while Glutathione supports cellular repair.

AFC Utsukushhii Gold:

Not just a Collection of Ingredients, but

a precisely engineered system for Cellular Health

Not just a Supplement. A System.

SCIENTIFICALLY ENGINEERED

Built on a foundation of 8 distinct international patents for targeted therapeutic action.

SYNERGISTIC FORMULA

Every component is chosen to amplify the effects of the others, from probiotics creating the right environment to antioxidants protecting new tissue.

MULTI-TARGETED ACTION

Simultaneously supports the gut, liver, immune system, and cellular integrity for comprehensive wellness..

CLINICALLY RECOGNIZED

Validated for its therapeutic potential with an official listing in MIMS as an adjuvant therapy.